Q: My 8-year-old (25kg) has a persistent 40°C fever that doesn't drop much with Acetaminophen and Dexibuprofen. Can I give more medicine?
- Myeongchan Kim, MD

- Jul 26
- 3 min read
Medically reviewed by Sang Hyun Ahn, MD
Content edited by Myeongchan Kim, MD
This post is a dramatization of a question and answer session experienced by our actual medical reviewers. Please note that this content is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

Question:
My 8-year-old son, who weighs 25kg, has a continuous fever and I am struggling to manage his fever reducers. I've been giving him 10ml of Acetaminophen and 10ml of Dexibuprofen. Since his fever of 40°C didn't go down after taking Acetaminophen, I gave him Dexibuprofen two hours later. Here is his schedule today:
02:00 Acetaminophen 10ml
08:00 Dexibuprofen 10ml
14:30 Acetaminophen 10ml
16:40 Dexibuprofen 10ml (fever wouldn't drop)
20:50 Acetaminophen 10ml
Even with the medication, his fever only drops to about 39°C. I'm worried about exceeding his daily limits. Can I give him more medicine if the fever persists?
Answer:
You have been working so hard managing your child's high fever all day. Let's review the current situation to ensure he stays safe.
Current Situation Summary
For an 8-year-old weighing 25kg, the appropriate dosage range is 250–375mg (about 8–12mL) for Acetaminophen and 125–175mg (about 10–15mL) for Dexibuprofen. The doses you are currently giving are well within the safe range, and you have correctly maintained the minimum 2-hour interval for alternating the medications. The main issue here is not the dosage, but rather that a high fever of 39–40°C persists despite the medication.
Medical Evaluation Needed Today
Please visit your pediatrician, an urgent care clinic, or the emergency room today if any of the following apply:
• The fever has lasted for 3 or more days, or is becoming more frequent and higher.
• Your child is lethargic, has poor eye contact, or shows decreased responsiveness.
• There has been no urine for over 8 hours, or his lips and tongue are very dry.
• He is breathing rapidly or his chest/ribs are retracting when breathing.
• He has repeated headaches, vomiting, or a stiff neck.
What You Can Do at Home Now
Do not increase the medication dose. Maintain the current dosage and intervals:
Acetaminophen: 10mL every 4–6 hours (maximum 5 times a day).
Dexibuprofen: 10mL every 6–8 hours.
Keep at least a 2-hour interval when alternating between the two different medications.
Focus on hydration. Give him a few sips of water, electrolyte drinks, or broth every 5–10 minutes. Check the color and frequency of his urine (no urine for over 8 hours is a strong sign of dehydration).
Adjust clothing and environment. Dress him in a single layer of thin clothing, keep the room temperature comfortable (around 22–24°C), and use a fan on a low setting if needed. Avoid wiping him down with a wet towel or giving tepid baths, as this can cause shivering and actually raise his core body temperature.
Record symptoms. Keep track of his fever patterns, other symptoms (like cough, rash, stomachache, or diarrhea), activity levels, and fluid intake to share with the doctor.
When you see the doctor, you can ask if specific tests (blood, urine, chest X-ray) or antibiotics are necessary, and what specific warning signs you should watch for if you are sent home to monitor him further.
In summary, while your medication dosages are within the safe range, your child needs a medical evaluation today because the high fever is not responding to the medication. Please contact your pediatrician or visit a local urgent care/ER to have him properly assessed.

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